Structure of PDB 3gn8 Chain A

Receptor sequence
>3gn8A (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
APTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKWA
KALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLV
INEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKD
GLKSQAVFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEM
VGGLLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQK
3D structure
PDB3gn8 An epistatic ratchet constrains the direction of glucocorticoid receptor evolution
ChainA
Resolution2.5 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V44 K48 Q66 M221 E224 N228 V47 K51 Q69 M224 E227 N231
BS02 DEX A M29 L32 N33 Q39 M70 M73 F92 Q111 F204 C205 T208 M32 L35 N36 Q42 M73 M76 F95 Q114 F207 C208 T211
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