Structure of PDB 3gmd Chain A

Receptor sequence
>3gmdA (length=264) Species: 10090 (Mus musculus) [Search protein sequence]
EFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVV
SRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTS
LSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKV
TYPMVAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMK
AVSGIVNAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKI
MEFFSLRYYNKDMF
3D structure
PDB3gmd Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11 beta-hydroxysteroid dehydrogenase type I.
ChainA
Resolution2.28 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S170 Y183 K187
Catalytic site (residue number reindexed from 1) S145 Y158 K162
Enzyme Commision number 1.1.1.146: 11beta-hydroxysteroid dehydrogenase.
1.1.1.201: 7beta-hydroxysteroid dehydrogenase (NADP(+)).
Interaction with ligand
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0050661 NADP binding
GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
Biological Process
GO:0008202 steroid metabolic process
GO:0030324 lung development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:3gmd, PDBe:3gmd, PDBj:3gmd
PDBsum3gmd
PubMed22901389
UniProtP50172|DHI1_MOUSE 11-beta-hydroxysteroid dehydrogenase 1 (Gene Name=Hsd11b1)

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