Structure of PDB 3gkz Chain A

Receptor sequence
>3gkzA (length=233) Species: 10090 (Mus musculus) [Search protein sequence]
EVQLQESGPSLVKPSQTLSLTCSVTGDSVTSGYWSWIRQFPGNKLDYMGY
ISYRGSTYYNPSLKSRISITRDTSKNQVYLQLKSVSSEDTATYYCSYFDS
DDYAMEYWGQGTSVTVSSGGGGSQIVLTQSPAIMSASPGEKVTLTCSASS
SVSSSHLYWYQQKPGSSPKLWIYSTSNLASGVPARFSGSGSGTSYSLTIS
SMEAEDAASYFCHQWSSFPFTFGSGTKLEIKRA
3D structure
PDB3gkz Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse-Methamphetamine and 3,4-methylenedioxymethamphetamine.
ChainA
Resolution1.9 Å
3D
structure
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Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 B40 A Y41 Y55 Y58 F106 E114 Y175 Y177 H230 W232 F237 Y33 Y47 Y50 F98 E106 Y158 Y160 H213 W215 F220 MOAD: Kd=10nM
PDBbind-CN: -logKd/Ki=8.00,Kd=10nM
External links