Structure of PDB 3gki Chain A

Receptor sequence
>3gkiA (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
QSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQELCPGFFFGQVS
LCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQFLQ
VTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKA
LGLLCGKDADACQATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNN
ATKGCDESVDEVTAPCSCQDCSIVC
3D structure
PDB3gki Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CLR A N41 Q79 L83 N86 P90 F108 T112 L176 Y192 M193 A201 P202 F203 N19 Q57 L61 N64 P68 F86 T90 L154 Y170 M171 A179 P180 F181
External links
PDB RCSB:3gki, PDBe:3gki, PDBj:3gki
PDBsum3gki
PubMed19563754
UniProtO15118|NPC1_HUMAN NPC intracellular cholesterol transporter 1 (Gene Name=NPC1)

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