Structure of PDB 3gg2 Chain A

Receptor sequence

>3gg2A (length=431) Species: 837 (Porphyromonas gingivalis)

SLDIAVVGIGYVGLVSATCFAELGANVRCIDTDRNKIEQLNSGTIPIYEP
GLEKMIARNVKAGRLRFGTEIEQAVPEADIIFIAVGTPAGEDGSADMSYV
LDAARSIGRAMSRYILIVTKSTVPVGSYRLIRKAIQEELDKREVLIDFDI
ASNPEFLKEGNAIDDFMKPDRVVVGVDSDRARELITSLYKPMLLNNFRVL
FMDIASAEMTKYAANAMLATRISFMNDVANLCERVGADVSMVRLGIGSDS
RIGSKFLYPGCGYGGSCFPKDVKALIRTAEDNGYRMEVLEAVERVNEKQK
SILFDKFSTYYKGNVQGRCVAIWGLSFKPGTDDMREAPSLVLIEKLLEVG
CRVRVYDPVAMKEAQKRLGDKVEYTTDMYDAVRGAEALFHVTEWKEFRMP
DWSALSQAMAASLVIDGRNVYELPFTLLNIG

3D structure

• PDB: 3gg2 Crystal structure of UDP-glucose 6-dehydrogenase from Porphyromonas gingivalis bound to product UDP-glucuronate
• Chain: A
• Resolution: 1.7 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): T199 E236 K288 N292 C344 D348
• Catalytic site (residue number reindexed from 1): T122 E159 K211 N215 C267 D271
• Enzyme Commision number: 1.1.1.22: UDP-glucose 6-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UGA	A	F233 L234 K235 E236 K288 N292 I299 F333 Y335 Y340 G341 C344 F345 F404 K405	F156 L157 K158 E159 K211 N215 I222 F256 Y258 Y263 G264 C267 F268 F327 K328
BS02	UGA	A	M244 K245 L270 L271 N272 R275	M167 K168 L193 L194 N195 R198
BS03	UGA	A	F333 Y335 E470	F256 Y258 E393

Gene Ontology

Molecular Function

• GO:0003979 UDP-glucose 6-dehydrogenase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0051287 NAD binding

Biological Process

• GO:0000271 polysaccharide biosynthetic process

External links

• PDB: RCSB:3gg2, PDBe:3gg2, PDBj:3gg2
• PDBsum: 3gg2
• UniProt: Q7MVC7