Structure of PDB 3gfw Chain A

Receptor sequence
>3gfwA (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
FQSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQT
LDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLK
KKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLID
FGIAGTVNYMPPEAIKDSKISPKSDVWSLGCILYYMTYGKTPFQQIINQI
SKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYV
QIQ
3D structure
PDB3gfw Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function.
ChainA
Resolution2.74 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D647 K649 N652 D664 T686
Catalytic site (residue number reindexed from 1) D133 K135 N138 D150 T156
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S22 A I531 G532 A551 E603 G605 D608 S611 A651 L654 I663 I17 G18 A37 E89 G91 D94 S97 A137 L140 I149 PDBbind-CN: -logKd/Ki=7.57,Kd=27nM
BindingDB: IC50=367nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3gfw, PDBe:3gfw, PDBj:3gfw
PDBsum3gfw
PubMed20383151
UniProtP33981|TTK_HUMAN Dual specificity protein kinase TTK (Gene Name=TTK)

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