Structure of PDB 3gf3 Chain A

Receptor sequence

>3gf3A (length=563) Species: 1512 ([Clostridium] symbiosum)

MYSMPGYFQNMPTIGKELVNPNPENEQEIKAVESDIHESIKKALDAGITS
EEKLNERGQLSAMQRINALIDPGTWCPLNSLFNPENNKFGTTNIVNGLGR
VDGKWVYIVASDNKKMAGAWVPGQAENLIRCSDAAKMMHLPLIYLLNCSG
VEFPNQDKVYPNRRGGGTPFFRNSELNQLGIPVIVGIYGTNPAGGGYHSI
SPTILIAHQDANMAVGGAGAEQIIAAQIENSKLKVPAPGSVPIHYDETGF
FREVYQNDLGVIDGIKKYISYLPAYNLEFFRVDTPKAPQLPAEDLYSIIP
MNQKRPYDIYEVIARLFDNSEFSEYKKGYGPEMVTGLAKVNGLLVGVIAN
VQGLLMNYPEYKQNSVGIGGKLYRQGLIKMNEFVTLCARDRIPLIWLQDT
TGIDVGDEAEKAELLGLGQSLIYSIENSKLPSLEITIRKASAAAHYVLGG
PQGNNTNVFSIGTGACEYYVMPGETAANAMYSRKLVKAQPIIGKMNDMIQ
MYTDKSRPKYCTEKGMVDEIVDMTEVRPYIQAFTEAAYQNPQSICPMHQM
LTPRSTREFETFG

3D structure

• PDB: 3gf3 An asymmetric model for Na+-translocating glutaconyl-CoA decarboxylases
• Chain: A
• Resolution: 1.75 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): V153 A195 G196 I420 A460 A461
• Catalytic site (residue number reindexed from 1): V151 A193 G194 I403 A443 A444
• Enzyme Commision number: 4.1.1.70: Transferred entry: 7.2.4.5.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	COO	A	M118 A119 S151 G152 V153 F155 Y162 T192 A195 G196	M116 A117 S149 G150 V151 F153 Y160 T190 A193 G194

Gene Ontology

Molecular Function

• GO:0004485 methylcrotonoyl-CoA carboxylase activity
• GO:0016874 ligase activity

Biological Process

• GO:0006552 L-leucine catabolic process

Cellular Component

• GO:1905202 methylcrotonoyl-CoA carboxylase complex

External links

• PDB: RCSB:3gf3, PDBe:3gf3, PDBj:3gf3
• PDBsum: 3gf3
• PubMed: 19654317
• UniProt: B7TVP1