Structure of PDB 3geq Chain A

Receptor sequence
>3geqA (length=272) Species: 9031 (Gallus gallus) [Search protein sequence]
GHMQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLL
DFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLAAANILVGEN
LVCKVADFGLARLPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV
PYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEY
LQAFLEDYFTSTEPQYQPGENL
3D structure
PDB3geq Comparative analysis of mutant tyrosine kinase chemical rescue.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 A388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D139 A141 A143 N144 D157
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PP2 A L273 V281 A293 K295 T338 M341 L393 L26 V34 A46 K48 T91 M94 L146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3geq, PDBe:3geq, PDBj:3geq
PDBsum3geq
PubMed19260709
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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