Structure of PDB 3gdh Chain A

Receptor sequence
>3gdhA (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
LPPEIAAVPELAKYWAQRYRLFSRFDDGIKLDREGWFSVTPEKIAEHIAG
RVSQSFKCDVVVDAFCGVGGNTIQFALTGMRVIAIDIDPVKIALARNNAE
VYGIADKIEFICGDFLLLASFLKADVVFLSPPWGGPDYATAETFDIRTMM
SPDGFEIFRLSKKITNNIVYFLPRNADIDQVASLAGPGGQVEIEQNFLNN
KLKTITAYFGD
3D structure
PDB3gdh Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MGP A K646 F670 S671 V672 S763 P764 W766 G768 Y771 R807 K836 K13 F37 S38 V39 S130 P131 W133 G135 Y138 R174 K203
BS02 SAH A S671 V672 F698 C699 G700 V701 G703 N704 D719 I720 F748 S763 P765 S38 V39 F65 C66 G67 V68 G70 N71 D86 I87 F115 S130 P132
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0001510 RNA methylation
GO:0036261 7-methylguanosine cap hypermethylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3gdh, PDBe:3gdh, PDBj:3gdh
PDBsum3gdh
PubMed19386620
UniProtQ96RS0|TGS1_HUMAN Trimethylguanosine synthase (Gene Name=TGS1)

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