Structure of PDB 3gd4 Chain A

Receptor sequence

>3gd4A (length=445) Species: 10090 (Mus musculus) [Search protein sequence]

PSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKE
LWFSDDPNVTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPNIENGGVAVL
TGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVK
SRTTLFRKIGDFRALEKISREVKSITVIGGGFLGSELACALGRKSQASGI
EVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGR
LLIKLKDGRKVETDHIVTAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQ
ARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYWH
QSMFWSDLGPDVGYEAIGLVDSSLPTVGVFAKAEASEITIPEDYGKGVIF
YLRDKVVVGIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIH

3D structure

PDB

3gd4 Redox-linked conformational dynamics in apoptosis-inducing factor

Chain

Resolution

2.24 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.6.99.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	I136 G137 G138 G139 T140 A141 V161 S162 E163 R171 P172 S175 K231 V232 T259 G260 R284 G436 D437 E452 H453 H454 A457 W482	I9 G10 G11 G12 T13 A14 V34 S35 E36 R44 P45 S48 K104 V105 T132 G133 R157 G309 D310 E325 H326 H327 A330 W355
BS02	NAD	A	L266 G307 G308 F309 L310 E313 P334 E335 K341 A396 V397 G398 E452 H453 W482 S483	L139 G180 G181 F182 L183 E186 P207 E208 K214 A269 V270 G271 E325 H326 W355 S356

Gene Ontology

	Molecular Function
GO:0016491	oxidoreductase activity
GO:0046983	protein dimerization activity

View graph for
Molecular Function

External links

PDB	RCSB:3gd4, PDBe:3gd4, PDBj:3gd4
PDBsum	3gd4
PubMed	19447115
UniProt	Q9Z0X1\|AIFM1_MOUSE Apoptosis-inducing factor 1, mitochondrial (Gene Name=Aifm1)

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