Structure of PDB 3gd2 Chain A

Receptor sequence
>3gd2A (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
GSTPDQQTLLHFIMDSYNKQRMPQEITNKILKEESAEENFLILTEMATNH
VQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKLPSGHS
DLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDR
QYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFAELLGRLTELRTFNH
HHAEMLMSWRVNDHKFTPLLEEIWDVQ
3D structure
PDB3gd2 Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064.
ChainA
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V299 H313 I317 K321 P463 L464 E467 V55 H69 I73 K77 P218 L219 E222
BS02 708 A M265 F284 H294 M328 F329 R331 I335 I352 Y361 M365 H447 W454 F461 W469 M22 F40 H50 M84 F85 R87 I91 I107 Y116 M120 H202 W209 F216 W224
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3gd2, PDBe:3gd2, PDBj:3gd2
PDBsum3gd2
PubMed19410460
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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