Structure of PDB 3gc0 Chain A

Receptor sequence
>3gc0A (length=278) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence]
SIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHTAIREVSLLK
ELQHRNIIELKSVIHHNHRLHLIFEYAENDLKKYMDKNPDVSMRVIKSFL
YQLINGVNFCHSRRCLHRDLKPQNLLLSVETPVLKIGDFGLARAFEIITL
WYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIF
EVLGLPDDTTWPGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTA
MLEMDPVKRISAKNALEHPYFSHNDFDP
3D structure
PDB3gc0 Structure of a cyclin-dependent kinase from Giardia lamblia.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D136 K138 Q140 N141 D159 T179
Catalytic site (residue number reindexed from 1) D119 K121 Q123 N124 D138 T149
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A G24 V29 A42 K44 Y93 A94 L143 G14 V19 A32 K34 Y76 A77 L126
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0030332 cyclin binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010468 regulation of gene expression
GO:0016310 phosphorylation
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3gc0, PDBe:3gc0, PDBj:3gc0
PDBsum3gc0
PubMed21904054
UniProtA8BZ95

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