Structure of PDB 3gay Chain A

Receptor sequence
>3gayA (length=319) Species: 5741 (Giardia intestinalis) [Search protein sequence]
PLCTLRQMLGEARKHKYGVGAFNVNNMEQIQGIMKAVVQLKSPVILQCSR
GALKYSDMIYLKKLCEAALEKHPDIPICIHLDHGDTLESVKMAIDLGFSS
VMIDASHHPFDENVRITKEVVAYAHARGVSVEAELGTLGGIEQNTVQLTE
PQDAKKFVELTGVDALAVAIGTSHGAYKFKSESDIRLAIDRVKTISDLTG
IPLVMHGSSSVPKDVKDMINKYGGKMPDAVGVPIESIVHAIGEGVCKINV
DSDSRMAMTGAIRKVFVEHPEKFDPRDYLGPGRDAITEMLIPKIKAFGSA
GHAGDYKVVSLEEAKAWYK
3D structure
PDB3gay Structural insights into the substrate binding and stereoselectivity of giardia fructose-1,6-bisphosphate aldolase.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.2.13: fructose-bisphosphate aldolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H84 H178 H210 H83 H174 H206
BS02 P6T A N24 S50 D83 H178 G179 K182 H210 G211 S213 N253 D255 S256 R259 N23 S49 D82 H174 G175 K178 H206 G207 S209 N249 D251 S252 R255 MOAD: Kd=20nM
Gene Ontology
Molecular Function
GO:0004332 fructose-bisphosphate aldolase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016829 lyase activity
GO:0016832 aldehyde-lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0030388 fructose 1,6-bisphosphate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3gay, PDBe:3gay, PDBj:3gay
PDBsum3gay
PubMed19236002
UniProtA8B2U2|ALF_GIAIC Fructose-bisphosphate aldolase (Gene Name=fba)

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