Structure of PDB 3g8o Chain A

Receptor sequence
>3g8oA (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
QLIPPLINLLMSIEPDVIYAGHDNTKDTSSSLLTSLNQLGERQLLSVVKW
SKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDL
ILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPL
EGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHD
LVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFHK
3D structure
PDB3g8o Rational design of orally-active, pyrrolidine-based progesterone receptor partial agonists.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 30X A L718 N719 L721 M756 M759 V760 L763 L797 L887 Y890 C891 T894 L36 N37 L39 M74 M77 V78 L81 L115 L205 Y208 C209 T212 MOAD: ic50=125nM
PDBbind-CN: -logKd/Ki=7.80,IC50=16nM
BindingDB: IC50=125nM,EC50=1300nM
External links
PDB RCSB:3g8o, PDBe:3g8o, PDBj:3g8o
PDBsum3g8o
PubMed19595590
UniProtP06401|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

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