Structure of PDB 3g5k Chain A

Receptor sequence
>3g5kA (length=183) Species: 9606 (Homo sapiens) [Search protein sequence]
HMSFSHVCQVGDPVLRGVAAPVERAQLGGPELQRLTQRLVQVMRRRRCVG
LSAPQLGVPRQVLALELPEALCRECPPRQRALRQMEPFPLRVFVNPSLRV
LDSRLVTFPEGCESVAGFLACVPRFQAVQISGLDPNGEQVVWQASGWAAR
IIQHEMDHLQGCLFIDKMDSRTFTNVYWMKVND
3D structure
PDB3g5k Structure and activity of human mitochondrial peptide deformylase, a novel cancer target
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G52 Q57 C114 E115 H156 E157 H160
Catalytic site (residue number reindexed from 1) G50 Q55 C112 E113 H154 E155 H158
Enzyme Commision number 3.5.1.88: peptide deformylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BB2 A C50 V51 G52 Q57 P111 E112 G113 C114 E115 W149 R152 H156 E157 H160 C48 V49 G50 Q55 P109 E110 G111 C112 E113 W147 R150 H154 E155 H158 PDBbind-CN: -logKd/Ki=9.52,Ki=0.3nM
BindingDB: IC50=1.5nM,Ki=0.300000nM
BS02 CO A Q57 C114 H156 H160 Q55 C112 H154 H158
Gene Ontology
Molecular Function
GO:0042586 peptide deformylase activity

View graph for
Molecular Function
External links
PDB RCSB:3g5k, PDBe:3g5k, PDBj:3g5k
PDBsum3g5k
PubMed19236878
UniProtQ9HBH1|DEFM_HUMAN Peptide deformylase, mitochondrial (Gene Name=PDF)

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