Structure of PDB 3g49 Chain A

Receptor sequence
>3g49A (length=263) Species: 10141 (Cavia porcellus) [Search protein sequence]
KFRPEMLQGKKVIVTGASKGIGREIAYHLAKMGAHVVVTARSKEALQKVV
ARCLELGAASAHYIAGSMEDMTFAEEFVAEAGNLMGGLDMLILNHVLYNR
LTFFHGEIDNVRKSMEVNFHSFVVLSVAAMPMLMQSQGSIAVVSSVAGKI
TYPLIAPYSASKFALDGFFSTLRSEFLVNKVNVSITLCILGLIDTETAIK
ATSGIYLGPASPKEECALEIIKGTALRQDEMYYVGSRWVPYLLGNPGRKI
MEFLSAAEYNWDN
3D structure
PDB3g49 N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.146: 11beta-hydroxysteroid dehydrogenase.
1.1.1.201: 7beta-hydroxysteroid dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G16 S18 G20 I21 R41 S42 M68 N94 V96 V143 S145 Y158 K162 L190 L192 I193 T195 T197 A198 G16 S18 G20 I21 R41 S42 M68 N94 V96 V143 S145 Y158 K162 L190 L192 I193 T195 T197 A198
BS02 3G4 A Y98 N99 S145 V146 A147 Y152 Y158 L192 Y206 Y98 N99 S145 V146 A147 Y152 Y158 L192 Y206 MOAD: Ki=287nM
Gene Ontology
Molecular Function
GO:0005496 steroid binding
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0050661 NADP binding
GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity
GO:0102196 cortisol dehydrogenase activity
Biological Process
GO:0006706 steroid catabolic process
GO:0008202 steroid metabolic process
GO:0030324 lung development
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Cellular Component
External links
PDB RCSB:3g49, PDBe:3g49, PDBj:3g49
PDBsum3g49
PubMed19473839
UniProtQ6QLL4|DHI1_CAVPO 11-beta-hydroxysteroid dehydrogenase 1 (Gene Name=HSD11B1)

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