Structure of PDB 3g45 Chain A

Receptor sequence
>3g45A (length=371) Species: 9606 (Homo sapiens) [Search protein sequence]
SNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDTSISRFGVNTENEDH
LAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDT
FITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEIL
AAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLL
QEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKK
VTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFF
QQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPD
AQDILDTLEDNRNWYQSMIPQ
3D structure
PDB3g45 Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety.
ChainA
Resolution2.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H410 H446 D447 D564 H123 H159 D160 D277
BS02 988 A Y274 H406 I582 M603 Q615 F618 Y28 H119 I295 M316 Q328 F331 PDBbind-CN: -logKd/Ki=8.36,IC50=4.4nM
BindingDB: IC50=70nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3g45, PDBe:3g45, PDBj:3g45
PDBsum3g45
PubMed20037581
UniProtQ07343|PDE4B_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4B (Gene Name=PDE4B)

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