Structure of PDB 3g3m Chain A

Receptor sequence
>3g3mA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
KELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADA
LGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTV
KKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMS
STGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLE
AGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWE
AYLSRLG
3D structure
PDB3g3m Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.10: orotate phosphoribosyltransferase.
4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5FU A S68 D70 H94 K125 M182 S183 P228 Q241 Y243 G261 R262 S35 D37 H61 K92 M149 S150 P195 Q208 Y210 G228 R229 PDBbind-CN: -logKd/Ki=5.96,Ki=1.1uM
BindingDB: Ki=98000nM
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3g3m, PDBe:3g3m, PDBj:3g3m
PDBsum3g3m
PubMed19260677
UniProtP11172|UMPS_HUMAN Uridine 5'-monophosphate synthase (Gene Name=UMPS)

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