Structure of PDB 3g2f Chain A

Receptor sequence
>3g2fA (length=305) Species: 9606 (Homo sapiens) [Search protein sequence]
SLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNI
YRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS
DWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGT
CVISDFGLSMRLTGNRLVISEVGTIRYMAPEVLEGAVNLRDCESALKQVD
MYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSR
EKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELM
MIWER
3D structure
PDB3g2f Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension.
ChainA
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D333 R337
Catalytic site (residue number reindexed from 1) D137 R141
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A I209 G212 Y214 G215 V217 A228 K230 M279 Y282 R337 L340 D351 I13 G16 Y18 G19 V21 A32 K34 M83 Y86 R141 L144 D155
BS02 MG A N338 D351 N142 D155
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3g2f, PDBe:3g2f, PDBj:3g2f
PDBsum3g2f
PubMed31797984
UniProtQ13873|BMPR2_HUMAN Bone morphogenetic protein receptor type-2 (Gene Name=BMPR2)

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