Structure of PDB 3g2d Chain A

Receptor sequence
>3g2dA (length=256) Species: 187420 (Methanothermobacter thermautotrophicus str. Delta H) [Search protein sequence]
AVLKIISWNVNGLRAVHRKGFLKWFMEEKPDILCLQEIKAAPEQLPRKLR
HVEGYRSFFTPAERKGYSGVAMYTKVPPSSLREGFGVERFDTEGRIQIAD
FDDFLLYNIYFPNGKMSEERLKYKLEFYDAFLEDVNRERDSGRNVIICGN
FNTAHREIDLARPKENSNVSGFLPVERAWIDKFIENGYVDTFRMFNSDPG
QYTWWSYRTRARERNVGWRLDYFFVNEEFKGKVKRSWILSDVMGSDHCPI
GLEIEL
3D structure
PDB3g2d Crystal Structure Analysis of DNA Uridine Endonuclease Mth212 Bound to DNA
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N10 N12 E38 Y111 N151 N153 D222 D247 H248
Catalytic site (residue number reindexed from 1) N9 N11 E37 Y110 N150 N152 D221 D246 H247
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A R65 Y68 N114 M117 R64 Y67 N113 M116
BS02 dna A G13 R15 A16 R19 K20 Q45 G67 Y208 R209 G12 R14 A15 R18 K19 Q44 G66 Y207 R208
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0008081 phosphoric diester hydrolase activity
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3g2d, PDBe:3g2d, PDBj:3g2d
PDBsum3g2d
PubMed20434457
UniProtO26314|UREND_METTH DNA uridine endonuclease (Gene Name=MTH_212)

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