Structure of PDB 3g15 Chain A

Receptor sequence
>3g15A (length=354) Species: 9606 (Homo sapiens) [Search protein sequence]
EQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLP
DTTATLGDEPRKVLLRLYGAAEAMVLESVMFAILAERSLGPKLYGIFPQG
RLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTM
EKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFC
HNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYD
YSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKE
EMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKR
KLGV
3D structure
PDB3g15 Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.32: choline kinase.
2.7.1.82: ethanolamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R117 L124 L144 R146 Q207 F208 I209 R213 G310 I329 D330 R37 L44 L64 R66 Q104 F105 I106 R110 G207 I226 D227
BS02 MG A N311 D330 N208 D227
BS03 HC6 A D306 Y333 Y354 F361 W420 W423 E434 F435 Y440 D203 Y230 Y251 F258 W317 W320 E331 F332 Y337 PDBbind-CN: -logKd/Ki=7.00,Kd=0.10uM
BS04 MG A D330 E332 D227 E229
External links
PDB RCSB:3g15, PDBe:3g15, PDBj:3g15
PDBsum3g15
PubMed20299452
UniProtP35790|CHKA_HUMAN Choline kinase alpha (Gene Name=CHKA)

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