Structure of PDB 3g0h Chain A

Receptor sequence

>3g0hA (length=408) Species: 9606 (Homo sapiens) [Search protein sequence]

SLLNKLIRSNLVDNTNQVEVLQRDPNSPLYSVKSFEELRLKPQLLQGVYA
MGFNRPSKIQENALPLMLAEPPQNLIAQSQSGTGKTAAFVLAMLSQVEPA
NKYPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKI
SEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIR
IQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREEETLDTIKQ
YYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQ
VALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFD
LPVDKDGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKHSMNILNRIQEHF
NKKIERLD

3D structure

PDB

3g0h The DEXD/H-box RNA Helicase DDX19 Is Regulated by an {alpha}-Helical Switch.

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	P170 T171 R199 K202 L203 T217 G219 T220 D223 K227 L228 F230 H253 Q256 H341 T342 R343 S364 G365 R372 T390 N391 V392	P111 T112 R140 K143 L144 T158 G160 T161 D164 K168 L169 F171 H194 Q197 H282 T283 R284 S305 G306 R313 T331 N332 V333
BS02	ANP	A	F112 Q119 G141 T142 G143 K144 T145 D398 R429 R432 F433	F53 Q60 G82 T83 G84 K85 T86 D339 R370 R373 F374

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

View graph for
Molecular Function

External links

PDB	RCSB:3g0h, PDBe:3g0h, PDBj:3g0h
PDBsum	3g0h
PubMed	19244245
UniProt	Q9UMR2\|DD19B_HUMAN ATP-dependent RNA helicase DDX19B (Gene Name=DDX19B)

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