Structure of PDB 3g0e Chain A

Receptor sequence
>3g0eA (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
GPTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSF
GKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSEL
KVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFIC
SKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNIL
LTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFE
SDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEM
YDIMKTCWDADPLKRPTFKQIVQLIEKQISES
3D structure
PDB3g0e KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D792 R796 N797 D810
Catalytic site (residue number reindexed from 1) D193 R197 N198 D211
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B49 A L595 V603 A621 Y672 C673 C674 G676 L799 C809 F811 L54 V62 A80 Y131 C132 C133 G135 L200 C210 F212 MOAD: Kd=20nM
PDBbind-CN: -logKd/Ki=7.70,Kd=20nM
BindingDB: Kd=0.370000nM,IC50=48nM,Ki=210nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3g0e, PDBe:3g0e, PDBj:3g0e
PDBsum3g0e
PubMed19164557
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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