Structure of PDB 3g03 Chain A

Receptor sequence
>3g03A (length=87) Species: 9606 (Homo sapiens) [Search protein sequence]
ETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB3g03 High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A L54 L57 G58 I61 M62 Y67 Q72 H73 V93 H96 Y100 L30 L33 G34 I37 M38 Y43 Q48 H49 V69 H72 Y76
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3g03, PDBe:3g03, PDBj:3g03
PDBsum3g03
PubMed19305137
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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