Structure of PDB 3fzs Chain A

Receptor sequence
>3fzsA (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
IAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKE
KFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKN
SLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFG
LPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIG
VLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQME
KDIA
3D structure
PDB3fzs Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design.
ChainA
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D549 A551 R553 N554 D567 L587
Catalytic site (residue number reindexed from 1) D130 A132 R134 N135 D148 L151
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B96 A E474 M478 V487 M502 L504 E509 L556 G566 D567 F568 E55 M59 V68 M83 L85 E90 L137 G147 D148 F149 MOAD: ic50=1.5uM
PDBbind-CN: -logKd/Ki=5.82,IC50=1.5uM
BindingDB: Kd=990nM,IC50=400nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3fzs, PDBe:3fzs, PDBj:3fzs
PDBsum3fzs
PubMed19244237
UniProtQ14289|FAK2_HUMAN Protein-tyrosine kinase 2-beta (Gene Name=PTK2B)

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