Structure of PDB 3fyl Chain A

Receptor sequence
>3fylA (length=74) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SHMCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDK
IRRKNCPACRYRKCLQAGMNLEAR
3D structure
PDB3fyl DNA binding site sequence directs glucocorticoid receptor structure and activity.
ChainA
Resolution1.63 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A C450 H451 Y452 K461 K465 K490 R510 C14 H15 Y16 K25 K29 K54 R74 PDBbind-CN: Kd=0.24uM
BS02 dna A S459 R466 R489 K490 R496 S23 R30 R53 K54 R60 PDBbind-CN: Kd=0.24uM
BS03 ZN A C440 C443 C460 C4 C7 C24
BS04 ZN A C476 C482 C492 C495 C40 C46 C56 C59
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3fyl, PDBe:3fyl, PDBj:3fyl
PDBsum3fyl
PubMed19372434
UniProtP06536|GCR_RAT Glucocorticoid receptor (Gene Name=Nr3c1)

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