Structure of PDB 3fxw Chain A

Receptor sequence
>3fxwA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
EPKKYAVTDDYQLSKQVLGLGVGKVLECFHRRTGQKCALKLLYDSPKARQ
EVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQER
DQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLK
LTDFGFAKEEKYDKSCDMWSLGVIMYILLCGFPPFGFPNPEWSEVSEDAK
QLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHW
DEVKEEMTSALATMRVDYDQV
3D structure
PDB3fxw High resolution crystal structure of mitogen-activated protein kinase-activated protein kinase 3/inhibitor 2 complex
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D166 K168 N171 D187
Catalytic site (residue number reindexed from 1) D132 K134 N137 D153
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F10 A L50 L52 V58 A71 K73 C120 M121 E122 L173 T186 D187 L18 L20 V25 A38 K40 C87 M88 E89 L139 T152 D153 PDBbind-CN: -logKd/Ki=5.96,IC50=1100nM
BindingDB: IC50=1100nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3fxw, PDBe:3fxw, PDBj:3fxw
PDBsum3fxw
PubMed
UniProtQ16644|MAPK3_HUMAN MAP kinase-activated protein kinase 3 (Gene Name=MAPKAPK3)

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