Structure of PDB 3fxv Chain A

Receptor sequence
>3fxvA (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
MELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEAFSAEENFLILTEMAT
NHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKHSDL
LEARIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQY
IKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHH
AEMLMSWRVHKFTPLLCEIWDV
3D structure
PDB3fxv Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist
ChainA
Resolution2.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K307 H317 E318 K325 L468 E471 K61 H71 E72 K79 L215 E218
BS02 643 A M269 F288 L291 M294 A295 F333 R335 S336 I339 M369 Y373 M23 F42 L45 M48 A49 F87 R89 S90 I93 M118 Y122 PDBbind-CN: -logKd/Ki=7.03,IC50=0.094uM
BindingDB: IC50=94nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0032052 bile acid binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0038183 bile acid signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3fxv, PDBe:3fxv, PDBj:3fxv
PDBsum3fxv
PubMed19328688
UniProtQ96RI1|NR1H4_HUMAN Bile acid receptor (Gene Name=NR1H4)

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