Structure of PDB 3fx4 Chain A

Receptor sequence
>3fx4A (length=325) Species: 9823 (Sus scrofa) [Search protein sequence]
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVGYRHIDCAAIY
GNELEIGEALQETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLA
DLQLEYLDLYLMHWPYAFERGDNPFPKNADGTIRYDATHYKDTWKALEAL
VAKGLVRALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHC
QARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEKYNRSPAQILL
RWQVQRKVICIPKSVTPSRILQNIQVFDFTFSPEEMKQLDALNKNLRFIV
PMLTVDGKRVPRDAGHPLYPFNDPY
3D structure
PDB3fx4 Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor.
ChainA
Resolution1.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D45 Y50 K80 H113
Catalytic site (residue number reindexed from 1) D45 Y50 K80 H113
Enzyme Commision number 1.1.1.19: glucuronate reductase.
1.1.1.2: alcohol dehydrogenase (NADP(+)).
1.1.1.20: glucuronolactone reductase.
1.1.1.372: D/L-glyceraldehyde reductase.
1.1.1.54: allyl-alcohol dehydrogenase.
1.6.-.-
Interaction with ligand
Gene Ontology
Molecular Function
GO:0004032 aldose reductase (NADPH) activity
GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
GO:0008106 alcohol dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0047655 allyl-alcohol dehydrogenase activity
GO:0047939 L-glucuronate reductase activity
GO:0047941 glucuronolactone reductase activity
GO:0047956 glycerol dehydrogenase (NADP+) activity
GO:0160163 S-nitrosoglutathione reductase (NADPH) activity
GO:1990002 methylglyoxal reductase (NADPH) (acetol producing) activity
Biological Process
GO:0006629 lipid metabolic process
GO:0019853 L-ascorbic acid biosynthetic process
GO:0042840 D-glucuronate catabolic process
GO:0046185 aldehyde catabolic process
GO:0110095 cellular detoxification of aldehyde
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3fx4, PDBe:3fx4, PDBj:3fx4
PDBsum3fx4
PubMed20036445
UniProtP50578|AK1A1_PIG Aldo-keto reductase family 1 member A1 (Gene Name=AKR1A1)

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