Structure of PDB 3fwl Chain A

Receptor sequence
>3fwlA (length=707) Species: 562 (Escherichia coli) [Search protein sequence]
LWLLLKLAIVFAVLIAIYGVYLDQKIRSRIDGKVWQLPAAVYGRMVNLEP
DMTISKNEMVKLLEATQYRQVSKMTRPGEFTVQANSIEMIRRPFDFPDSK
EGQVRARLTFDGDHLATIVNMENNRQFGFFRLDPRLITMISSPNGEQRLF
VPRSGFPDLLVDTLLATEDRHFYEHDGISLYSILTQQLVKNLFLSSERSY
WRKANEAYMALIMDARYSKDRILELYMNEVYLGQSGDNEIRGFPLASLYY
FGRPVEELSLDQQALLVGMVKGASIYNPWRNPKLALERRNLVLRLLQQQQ
IIDQELYDMLSARPVISPQPAFMQLVRQELQAKLGDKVKDLSGVKIFTTF
DSVAQDAAEKAAVEGIPALKKQRKLSDLETAIVVVDRFSGEVRAMVGGSE
PQFAGYNRAMQARRSIGSLAKPATYLTALSQPKIYRLNTWIADAPIALRQ
PNGQVWSPQNDDRRYSESGRVMLVDALTRSMNVPTVNLGMALGLPAVTET
WIKLGVPKDQLHPVPAMLLGALNLTPIEVAQAFQTIASGGNRAPLSALRS
VIAEDGKVLYQSFPQAERAVPAQAAYLTLWTMQQVVQRGTGRQLGAKYPN
LHLAGKTGTTNNNVDTWFAGIDGSTVTITWVGRDNNQPTKLYGASGAMSI
YQRYLANQTPTPLNLVPPEDIADMGVDYDGNFVCSGGMRILPVWTSDPQS
LCQQSEM
3D structure
PDB3fwl Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli.
ChainA
Resolution3.086 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.99.28: peptidoglycan glycosyltransferase.
3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 M0E A Q271 K274 R286 Q318 E323 V354 K355 G356 S358 I359 Q187 K190 R202 Q234 E239 V270 K271 G272 S274 I275
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008658 penicillin binding
GO:0008955 peptidoglycan glycosyltransferase activity
Biological Process
GO:0009252 peptidoglycan biosynthetic process
GO:0046677 response to antibiotic
Cellular Component
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3fwl, PDBe:3fwl, PDBj:3fwl
PDBsum3fwl
PubMed19458048
UniProtP02919|PBPB_ECOLI Penicillin-binding protein 1B (Gene Name=mrcB)

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