Structure of PDB 3fw7 Chain A

Receptor sequence
>3fw7A (length=498) Species: 3467 (Eschscholzia californica) [Search protein sequence]
AGNDLLSCLTFNGVRNHTVFSADSDSDFNRFLHLSIQNPLFQNSLISKPS
AIILPGSKEELSNTIRCIRKGSWTIRLRSGGASYEGLSYTSDTPFILIDL
MNLNRVSIDLESETAWVESGSTLGELYYAITESSSKLGFTAGWCPTVGTG
GHISGGGFGMMSRKYGLAADNVVDAILIDANGAILDRQAMGEDVFWAIRG
GGGGVWGAIYAWKIKLLPVPEKVTVFRVTKNVAIDEATSLLHKWQFVAEE
LEEDFTLSVLGGADEKQVWLTMLGFHFGLKTVAKSTFDLLFPELGLVEED
YLEMSWGESFAYLAGLETVSQLNNRFLKFDERAFKTKVDLTKEPLPSKAF
YGLLERLSKEPNGFIALNGFGGQMSKISSDFTPFPHRSGTRLMVEYIVAW
NQSEQKKKTEFLDWLEKVYEFMKPFVSKNPRLGYVNHIDLDLGGIDWGNK
TVVNNAIEISRSWGESYFLSNYERLIRAKTLIDPNNVFNHPQSIPPMA
3D structure
PDB3fw7 A concerted mechanism for berberine bridge enzyme.
ChainA
Resolution1.825 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.21.3.3: reticuline oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A L99 R100 S101 G102 G103 A104 S105 Y106 S110 S141 G164 W165 C166 V169 G170 G173 H174 F180 G225 G226 A230 I231 Y456 N458 L77 R78 S79 G80 G81 A82 S83 Y84 S88 S119 G142 W143 C144 V147 G148 G151 H152 F158 G203 G204 A208 I209 Y434 N436
BS02 MG A D45 D47 D23 D25
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0050468 reticuline oxidase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0009820 alkaloid metabolic process
Cellular Component
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3fw7, PDBe:3fw7, PDBj:3fw7
PDBsum3fw7
PubMed
UniProtP30986|RETO_ESCCA Reticuline oxidase (Gene Name=BBE1)

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