Structure of PDB 3fvy Chain A

Receptor sequence
>3fvyA (length=718) Species: 9606 (Homo sapiens) [Search protein sequence]
QYILPNDIGVSSLDCREAFRLLSPTERLYAYHLSRAAWYGGLAVLLQTSP
EAPYIYALLSRLFRAQDPDQLHQHALAEGLTEEEYQAFLVYAAGVYSNMG
NYKSFGDTKFVPNLPKEKLERVILGSEAAQQHPEEVRGLWQTCGELMFSL
EPRLRHLGLGKEGITTYFSGNCTMEDAKLAQDFLDSQNLSAYNTRLFKEV
DGEGKPYYEVRLASVLGSESEVTSKLKSYEFRGSPFQVTRGDYAPILQKV
VEQLEKAKAYAANSHQGQMLAQYIESFTQGSIEAHKRGSRFWIQDKGPIV
ESYIGFIESYRDPFGSRGEFEGFVAVVNKAMSAKFERLVASAEQLLKELP
WPPTFEKDKFLTPDFTSLDVLTFAGSGIPAGINIPNYDDLRQTEGFKNVS
LGNVLAVAYATQREKLTFLEEDDKDLYILWKGPSFDVQVGLHELLGHGSG
KLFVQDEKGAFNFDQETVINPETGEQIQSWYRSGETWDSKFSTIASSYEE
CRAESVGLYLCLHPQVLEIFGFEGADAEDVIYVNWLNMVRAGLLALEFYT
PEAFNWRQAHMQARFVILRVLLEAGEGLVTITPTTGSDGRPDARVRLDRS
KIRSVGKPALERFLRRLQVLKSTGDVAGGRALYEGYATVTDAPPECFLTL
RDTVLLRKESRKLIVQPNTRLEGSDVQLLEYEASAAGLIRSFSERFPEDG
PELEEILTQLATADARFW
3D structure
PDB3fvy Entropy-driven binding of opioid peptides induces a large domain motion in human dipeptidyl peptidase III.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.14.4: dipeptidyl-peptidase III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H450 H455 E508 H442 H447 E500
BS02 MG A G164 G167 G160 G163
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0030163 protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3fvy, PDBe:3fvy, PDBj:3fvy
PDBsum3fvy
PubMed22493238
UniProtQ9NY33|DPP3_HUMAN Dipeptidyl peptidase 3 (Gene Name=DPP3)

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