Structure of PDB 3fv5 Chain A

Receptor sequence
>3fv5A (length=180) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
GLEPVRRRPGMYTDTTRPNHLGQEVIDNSVDEALAGHAKRVDVILHADQS
LEVIDDGRGMPVDIHPEEGVPAVELILCRLISVVNALSKRVEVNVRRDGQ
VYNIAFENGEKVQDLQVVGTCGKRNTGTSVHFWPDETFFDSPRFSVSRLT
HVLKAKAVLCPGVEITFKDEINNTEQRWCY
3D structure
PDB3fv5 Design and syntheses of novel C7-derived-aminobenzimidazole ureas: bacterial gyrase/topoisomerase IV inhibitors with potent Gram-positve antibacterial activity
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1EU A V39 S43 E46 V67 D69 R72 G73 M74 P75 R132 T163 V165 V25 S29 E32 V53 D55 R58 G59 M60 P61 R97 T128 V130
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3fv5, PDBe:3fv5, PDBj:3fv5
PDBsum3fv5
PubMed
UniProtP20083|PARE_ECOLI DNA topoisomerase 4 subunit B (Gene Name=parE)

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