Structure of PDB 3frg Chain A

Receptor sequence
>3frgA (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
ISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQE
RDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLST
PALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESV
LENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMS
LLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLEL
YRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVH
PLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQA
3D structure
PDB3frg Quinolines as a novel structural class of potent and selective PDE4 inhibitors: optimisation for oral administration.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SK4 A M347 N395 F414 M431 Q443 F446 M195 N243 F262 M279 Q291 F294 MOAD: ic50=3.98nM
PDBbind-CN: -logKd/Ki=8.40,IC50=3.98nM
BindingDB: IC50=3.98nM
BS02 ZN A H238 H274 D275 D392 H86 H122 D123 D240
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:3frg, PDBe:3frg, PDBj:3frg
PDBsum3frg
PubMed19195882
UniProtQ07343|PDE4B_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4B (Gene Name=PDE4B)

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