Structure of PDB 3fpx Chain A

Receptor sequence

>3fpxA (length=499) Species: 5327 (Trametes hirsuta)

AVGPVADLTITDAAVSPDGFSRQAVVVNGVTPGPLVAGNIGDRFQLNVID
NLTNHTMLKSTSIHWHGFFQHGTNWADGPAFINQCPISPGHSFLYDFQVP
DQAGTFWYHSHLSTQYCDGLRGPFVVYDPNDPHASRYDVDNDDTVITLAD
WYHTAAKLGPRFPGGADATLINGKGRAPSDSVAELSVIKVTKGKRYRFRL
VSLSCNPNHTFSIDGHNLTIIEVDSVNSQPLEVDSIQIFAAQRYSFVLDA
NQAVDNYWIRANPNFGNVGFDGGINSAILRYDGAPAVEPTTNQTTSVKPL
NEVDLHPLVSTPVPGSPSSGGVDKAINMAFNFNGSNFFINGASFVPPTVP
VLLQILSGAQTAQDLLPSGSVYVLPSNASIEISFPATAAAPGAPHPFHLH
GHTFAVVRSAGSTVYNYDNPIFRDVVSTGTPAAGDNVTIRFDTNNPGPWF
LHCHIDFHLEGGFAVVMAEDTPDVKAVNPVPQAWSDLCPTYDALDPNDQ

3D structure

• PDB: 3fpx Crystallization and preliminary X-ray analysis of a four-copper laccase from Coriolus hirsutus
• Chain: A
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H64 H66 H109 H111 H395 H398 H400 H452 C453 H454 I455 H458 F463
• Catalytic site (residue number reindexed from 1): H64 H66 H109 H111 H395 H398 H400 H452 C453 H454 I455 H458 F463
• Enzyme Commision number: 1.10.3.2: laccase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MAN	A	S21 Q23	S21 Q23
BS02	CU	A	H111 H400 H452	H111 H400 H452
BS03	CU	A	H66 H109 H454	H66 H109 H454
BS04	CU	A	H64 H66 H398	H64 H66 H398
BS05	CU	A	H395 C453 H458	H395 C453 H458

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0052716 hydroquinone:oxygen oxidoreductase activity

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:3fpx, PDBe:3fpx, PDBj:3fpx
• PDBsum: 3fpx
• UniProt: B2L9C1