Structure of PDB 3fpm Chain A

Receptor sequence
>3fpmA (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
PQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALK
MLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDG
GELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL
YTSKRPNAILKLTDFGFAKETTSTPYYVAPEVLGPEKYDKSCDMWSLGVI
MYILLCGYPPFGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQ
RMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED
3D structure
PDB3fpm Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
ChainA
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D186 K188 E190 N191 D207 S216 T226
Catalytic site (residue number reindexed from 1) D143 K145 E147 N148 D164 S173 T174
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 793 A L72 N75 V78 A91 K93 M138 E139 L141 E190 D207 L29 N32 V35 A48 K50 M95 E96 L98 E147 D164 PDBbind-CN: -logKd/Ki=5.05,IC50=8.9uM
BindingDB: IC50=8900nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3fpm, PDBe:3fpm, PDBj:3fpm
PDBsum3fpm
PubMed19364658
UniProtP49137|MAPK2_HUMAN MAP kinase-activated protein kinase 2 (Gene Name=MAPKAPK2)

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