Structure of PDB 3fnu Chain A

Receptor sequence
>3fnuA (length=326) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
EFDNVELKDLANVLSFGEAKLGDNGQKFNFLFHTASSNVWVPSIKCTSES
CESKNHYDSSKSKTYEKDDTPVKLTSKAGTISGIFSKDLVTIGKLSVPYK
FIEMTEIVGFEPFYSESDVDGVFGLGWKDLSIGSIDPYIVELKTQNKIEQ
AVYSIYLPPENKNKGYLTIGGIEERFFDGPLNYEKLNHDLMWQVDLDVHF
GNVSSKKANVILDSATSVITVPTEFFNQFVESASVFKVPFLSLYVTTCGN
TKLPTLEYRSPNKVYTLEPKQYLEPLENIFSALCMLNIVPIDLEKNTFVL
GDPFMRKYFTVYDYDNHTVGFALAKN
3D structure
PDB3fnu Crystal structures of the histo-aspartic protease (HAP) from Plasmodium falciparum.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H32 S35 N37 W39 S75 D215 T218
Catalytic site (residue number reindexed from 1) H33 S36 N38 W40 S76 D213 T216
Enzyme Commision number 3.4.23.39: plasmepsin II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 006 A W39 F109A F111 Y112 V120 W40 F110 F113 Y114 V122 PDBbind-CN: -logKd/Ki=6.16,IC50=0.69uM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3fnu, PDBe:3fnu, PDBj:3fnu
PDBsum3fnu
PubMed19285084
UniProtQ8IM15|PLM3_PLAF7 Plasmepsin III (Gene Name=PMIII)

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