Structure of PDB 3fnt Chain A

Receptor sequence
>3fntA (length=323) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
DNVELKDLANVLSFGEAKLGDNGQKFNFLFHTASSNVWVPSIKCTSESCE
SKNHYDSSKSKTYEKDDTPVKLTSKAGTISGIFSKDLVTIGKLSVPYKFI
EMTEIVGFEPFYSESDVDGVFGLGWKDLSIGSIDPYIVELKTQNKIEQAV
YSIYLPPENKNKGYLTIGGIEERFFDGPLNYEKLNHDLMWQVDLDVHFGN
VSSKKANVILDSATSVITVPTEFFNQFVESASVFKVPFLSLYVTTCGNTK
LPTLEYRSPNKVYTLEPKQYLEPLENIFSALCMLNIVPIDLEKNTFVLGD
PFMRKYFTVYDYDNHTVGFALAK
3D structure
PDB3fnt Crystal structures of the histo-aspartic protease (HAP) from plasmodium falciparum.
ChainA
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H32 S35 N37 W39 S75 D215 T218
Catalytic site (residue number reindexed from 1) H31 S34 N36 W38 S74 D211 T214
Enzyme Commision number 3.4.23.39: plasmepsin II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H32 K76 D215 A217 T218 S219 L291 H31 K75 D211 A213 T214 S215 L291
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3fnt, PDBe:3fnt, PDBj:3fnt
PDBsum3fnt
PubMed19285084
UniProtQ8IM15|PLM3_PLAF7 Plasmepsin III (Gene Name=PMIII)

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