Structure of PDB 3fl3 Chain A

Receptor sequence
>3fl3A (length=121) Species: 9913 (Bos taurus) [Search protein sequence]
KETAAAKFERQHMDSSTSSSNYCNLMMCCRNLTKDRCKPVNTFVHESLAD
VQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTTQAN
KHIIVACEGNPYVPVHFDASV
3D structure
PDB3fl3 Toward an antitumor form of bovine pancreatic ribonuclease: The crystal structure of three noncovalent dimeric mutants
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H12 K41 H119 F120 D121
Catalytic site (residue number reindexed from 1) H12 K38 H116 F117 D118
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A N44 T45 F120 D121 A122 N41 T42 F117 D118 A119
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

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Cellular Component
External links
PDB RCSB:3fl3, PDBe:3fl3, PDBj:3fl3
PDBsum3fl3
PubMed19280639
UniProtP61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)

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