Structure of PDB 3fhr Chain A

Receptor sequence
>3fhrA (length=273) Species: 9606 (Homo sapiens) [Search protein sequence]
EPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKAR
QEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQE
RDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVL
KLTDFGFAKETEKYDKSCDMWSLGVIMYILLCGFPPFGFPNPEWSEVSED
AKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKD
HWDEVKEEMTSALATMRVDYDQV
3D structure
PDB3fhr High-resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D166 K168 N171 D187
Catalytic site (residue number reindexed from 1) D133 K135 N138 D154
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P4O A L50 L52 G53 V58 A71 K73 M121 E122 L173 T186 D187 L18 L20 G21 V26 A39 K41 M89 E90 L140 T153 D154 PDBbind-CN: -logKd/Ki=6.68,IC50=210nM
BindingDB: IC50=210nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3fhr, PDBe:3fhr, PDBj:3fhr
PDBsum3fhr
PubMed19937655
UniProtQ16644|MAPK3_HUMAN MAP kinase-activated protein kinase 3 (Gene Name=MAPKAPK3)

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