Structure of PDB 3fhb Chain A

Receptor sequence
>3fhbA (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]
SMKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQ
IARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINS
PELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQ
LQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSK
LGNRKLLWHGTNMAVVAAILTSGLRIMPHSGGRVGKGIYFASENSKSAGY
VIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSVIARGHT
EPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRL
RYLLEVH
3D structure
PDB3fhb Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S422 Y425 E514
Catalytic site (residue number reindexed from 1) S247 Y250 E339
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAB A H384 G385 Y414 F415 A416 S422 Y425 E514 H209 G210 Y239 F240 A241 S247 Y250 E339 MOAD: Kd>2uM
PDBbind-CN: -logKd/Ki=5.70,Kd=2uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:3fhb, PDBe:3fhb, PDBj:3fhb
PDBsum3fhb
PubMed19354255
UniProtQ9Y6F1|PARP3_HUMAN Protein mono-ADP-ribosyltransferase PARP3 (Gene Name=PARP3)

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