Structure of PDB 3ffk Chain A

Receptor sequence
>3ffkA (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
EHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLR
NGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFES
ATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLFQVKGRRVVRATEVP
VSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSG
RARVHVSEEGTEPEAMLQVLGPKPALPAGTEDTAKEDAANRKLAKLYKVS
NGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEE
RKAALKTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQ
3D structure
PDB3ffk Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A G186 D187 E209 D259 G159 D160 E182 D232
BS02 CA A G65 D66 E97 V145 G38 D39 E70 V118
BS03 CA A D109 G114 A116 D82 G87 A89
BS04 CA A E302 D303 E327 E275 D276 E300
Gene Ontology
Molecular Function
GO:0051015 actin filament binding

View graph for
Molecular Function
External links
PDB RCSB:3ffk, PDBe:3ffk, PDBj:3ffk
PDBsum3ffk
PubMed19666512
UniProtP06396|GELS_HUMAN Gelsolin (Gene Name=GSN)

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