Structure of PDB 3fei Chain A

Receptor sequence
>3feiA (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKSLAKRIYEAYLKNFNMNKVKARVILSPFVIHDMETLCMAEKEAEVRI
FHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLS
SVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDD
SDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFL
FPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
3D structure
PDB3fei Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists
ChainA
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T288 L302 N303 Q305 V306 L309 K310 P458 L459 E462 T66 L80 N81 Q83 V84 L87 K88 P236 L237 E240
BS02 CTM A F273 C275 C276 S280 Y314 F318 M330 V332 M355 H440 Y464 F51 C53 C54 S58 Y92 F96 M108 V110 M133 H218 Y242 MOAD: ic50=0.02uM
PDBbind-CN: -logKd/Ki=7.70,IC50=0.02uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3fei, PDBe:3fei, PDBj:3fei
PDBsum3fei
PubMed19326383
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

[Back to BioLiP]