Structure of PDB 3fe1 Chain A

Receptor sequence
>3fe1A (length=381) Species: 9606 (Homo sapiens) [Search protein sequence]
MELAVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVG
DAAKSQAALNPHNTVFDAKRLIGRKFADTTVQSDMKHWPFRVVSEGGKPK
VRVCYRGEDKTFYPEEISSMVLSKMKETAEAYLGQPVKHAVITVPAYFND
SQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFDLGG
GTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKD
LSGNKRALRRLRTACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARF
EELCSDLFRSTLEPVEKALRDAKLDKAQIHDVVLVGGSTRIPKVQKLLQD
FFNGKELNKSINPDEAVAYGAAVQAAVLMGD
3D structure
PDB3fe1 Crystal structures of the ATPase domains of four human Hsp70 isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D12 S18 F46 T47 K73 E177 D201
Catalytic site (residue number reindexed from 1) D8 S14 F42 T43 K69 E173 D197
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A T16 Y17 G203 G204 E270 K273 R274 S277 G341 T12 Y13 G199 G200 E266 K269 R270 S273 G337
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone

View graph for
Molecular Function
External links
PDB RCSB:3fe1, PDBe:3fe1, PDBj:3fe1
PDBsum3fe1
PubMed20072699
UniProtP17066|HSP76_HUMAN Heat shock 70 kDa protein 6 (Gene Name=HSPA6)

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