Structure of PDB 3fde Chain A

Receptor sequence
>3fdeA (length=209) Species: 10090 (Mus musculus) [Search protein sequence]
MPANHFGPIPGVPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLVL
AGGYEDDVDNGNYFTYTGSGGRDLSGNKRTAGQSSDQKLTNNNRALALNC
HSPINEKGAEAEDWRQGKPVRVVRNMKGGKHSKYAPAEGNRYDGIYKVVK
YWPERGKSGFLVWRYLLRRDDTEPEPWTREGKDRTRQLGLTMQYPEGYLE
ALANKEKSR
3D structure
PDB3fde UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
ChainA
Resolution1.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A F437 R438 V451 A452 G453 A468 G470 Y471 D474 Y483 T484 S486 R496 K544 F20 R21 V34 A35 G36 A51 G53 Y54 D57 Y66 T67 S69 R79 K127
BS02 dna A R448 H450 H455 R457 S458 N494 R496 N508 R31 H33 H38 R40 S41 N77 R79 N91
External links
PDB RCSB:3fde, PDBe:3fde, PDBj:3fde
PDBsum3fde
PubMed19077538
UniProtQ8VDF2|UHRF1_MOUSE E3 ubiquitin-protein ligase UHRF1 (Gene Name=Uhrf1)

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