Structure of PDB 3fcs Chain A

Receptor sequence
>3fcsA (length=913) Species: 9606 (Homo sapiens) [Search protein sequence]
LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEET
GGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSW
SDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNT
LSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPV
ADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNT
TEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNG
DGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGT
QLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLR
SRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRA
QPVVKASVQLLVQDSLNPAVKSCVLPQTKTPVSCFNIQMCVGATGHNIPQ
KLSLNAELQLDRQKPRQGRRVLLLGSQQAGTTLNLDLGGKHSPICHTTMA
FLRDEADFRDKLSPIVLSLNVSLPPTEAGMAPAVVLHGDTHVQEQTRIVL
DCGEDDVCVPQLQLTASVTGSPLLVGADNVLELQMDAANEGEGAYEAELA
VHLPQGAHYMRALSNVEFERLICNQKKENETRVVLCELGNPMKKNAQIGI
AMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELR
GNSFPASLVVAASWGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQPSDL
LYILDIQPQGGLQCFPQPPVNPLKVDWDPVLVSCDSAPCTVVQCDLQEMA
RGQRAMVTVLAFLWLPSLYQRPLDQFVLQSHAWFNVSSLPYAVPPLSLPR
GEAQVWTQLLRAC
3D structure
PDB3fcs Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E243 D245 D247 T250 T251 E252 E243 D245 D247 T250 T251 E252
BS02 CA A D297 N299 D301 R303 D305 D297 N299 D301 R303 D305
BS03 CA A D365 D367 D369 Y371 D373 D365 D367 D369 Y371 D373
BS04 CA A D426 D428 N430 Y432 D434 D426 D428 N430 Y432 D434
BS05 CA A C602 D605 V607 E642 C602 D605 V607 E642
Gene Ontology
Molecular Function
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0050840 extracellular matrix binding
GO:0060090 molecular adaptor activity
GO:0070051 fibrinogen binding
Biological Process
GO:0001525 angiogenesis
GO:0002687 positive regulation of leukocyte migration
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0033627 cell adhesion mediated by integrin
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0031092 platelet alpha granule membrane
GO:0070062 extracellular exosome
GO:0070442 integrin alphaIIb-beta3 complex
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3fcs, PDBe:3fcs, PDBj:3fcs
PDBsum3fcs
PubMed19111664
UniProtP08514|ITA2B_HUMAN Integrin alpha-IIb (Gene Name=ITGA2B)

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