Structure of PDB 3fb1 Chain A

Receptor sequence
>3fb1A (length=281) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYT
KIPNFPQTSHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMK
LLGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEA
FGTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPA
ECTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLK
PNHEEVLATGAQRAELMQSWFEKIIEKLPKD
3D structure
PDB3fb1 Purine nucleoside phosphorylase from Schistosoma mansoni in complex with ribose-1-phosphate.
ChainA
Resolution2.002 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259
Catalytic site (residue number reindexed from 1) S32 H60 H82 Y84 E85 A112 M215 S216 N239 S241 H253
Enzyme Commision number 2.4.2.1: purine-nucleoside phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 R1P A G34 S35 R86 H88 Y90 N117 A118 Y202 M221 S222 G31 S32 R80 H82 Y84 N111 A112 Y196 M215 S216
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0047975 guanosine phosphorylase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0009116 nucleoside metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3fb1, PDBe:3fb1, PDBj:3fb1
PDBsum3fb1
PubMed21169694
UniProtQ9BMI9

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