Structure of PDB 3f8d Chain A

Receptor sequence
>3f8dA (length=308) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence]
VKPGEKFDVIIVGLGPAAYGAALYSARYMLKTLVIGETPGGQLTEAGIVD
DYLGLIEIQASDMIKVFNKHIEKYEVPVLLDIVEKIENREFVVKTKRKGE
FKADSVILGIGVKRRKLGVPGEQEFAGRGISYCSVADAPLFKNRVVAVIG
GGDSALEGAEILSSYSTKVYLIHRRDTFKAQPIYVETVKKKPNVEFVLNS
VVKEIKGDKVVKQVVVENLKTGEIKELNVNGVFIEIGFDPPTDFAKSNGI
ETDTNGYIKVDEWMRTSVPGVFAAGDCTSAWLGFRQVITAVAQGAVAATS
AYRYVTEK
3D structure
PDB3f8d Structure and stability of a thioredoxin reductase from Sulfolobus solfataricus: a thermostable protein with two functions
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C144 A147 D148
Catalytic site (residue number reindexed from 1) C133 A136 D137
Enzyme Commision number 1.6.99.3: Deleted entry.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A V21 G22 L23 G24 P25 A26 G45 E46 T47 G50 Q51 E54 A55 V58 D60 I91 V92 G120 I121 G122 C144 A147 G286 D287 R296 Q297 V298 V12 G13 L14 G15 P16 A17 G36 E37 T38 G41 Q42 E45 A46 V49 D51 I82 V83 G109 I110 G111 C133 A136 G275 D276 R285 Q286 V287
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0019430 removal of superoxide radicals
GO:0045454 cell redox homeostasis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3f8d, PDBe:3f8d, PDBj:3f8d
PDBsum3f8d
PubMed19110078
UniProtQ8X236

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