Structure of PDB 3f6g Chain A

Receptor sequence
>3f6gA (length=121) Species: 173 (Leptospira interrogans) [Search protein sequence]
KVLTIKSCNIHSGIGIRPHAQIELEYQGKIHKEISEGDGGYDAFMNALTK
ITNRLGISIPKLIDYEVRIPPGGKTDALVETRITWNKSLEEDQTFKTMGV
HPDQTVAAVHATEKMLNQILQ
3D structure
PDB3f6g Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.21: (R)-citramalate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ILE A G428 Y430 D431 G39 Y41 D42 PDBbind-CN: -logKd/Ki=4.72,Ki=19uM
BS02 ILE A T464 A466 P493 D494 Q495 T75 A77 P102 D103 Q104 PDBbind-CN: -logKd/Ki=4.72,Ki=19uM
Gene Ontology
Molecular Function
GO:0003852 2-isopropylmalate synthase activity
Biological Process
GO:0009098 L-leucine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3f6g, PDBe:3f6g, PDBj:3f6g
PDBsum3f6g
PubMed19351325
UniProtQ8F3Q1|CIMA_LEPIN (R)-citramalate synthase CimA (Gene Name=cimA)

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