Structure of PDB 3f61 Chain A

Receptor sequence
>3f61A (length=271) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
MTTPSHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDP
SFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTL
RDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATN
AVKVMDFGIAAQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGD
SPDSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEM
RADLVRVHNGEPPEAPKVLTD
3D structure
PDB3f61 Auto-activation mechanism of the Mycobacterium tuberculosis PknB receptor Ser/Thr kinase.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 A142 N143 D156
Catalytic site (residue number reindexed from 1) D138 K140 A142 N143 D156
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G18 F19 V25 K40 M92 V95 T99 K140 A142 M145 M155 G18 F19 V25 K40 M92 V95 T99 K140 A142 M145 M155
BS02 MG A N143 D156 N143 D156
BS03 MG A K140 P141 A142 K140 P141 A142
BS04 MG A G20 M22 S23 G20 M22 S23
BS05 MG A N127 A267 N127 A248
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3f61, PDBe:3f61, PDBj:3f61
PDBsum3f61
PubMed19008858
UniProtP9WI81|PKNB_MYCTU Serine/threonine-protein kinase PknB (Gene Name=pknB)

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